Feline leukemia virus outbreak in the critically endangered Iberian lynx ( Lynx pardinus ): high-throughput sequencing of envelope variable region A and experimental transmission
Identifieur interne : 002288 ( Main/Exploration ); précédent : 002287; suivant : 002289Feline leukemia virus outbreak in the critically endangered Iberian lynx ( Lynx pardinus ): high-throughput sequencing of envelope variable region A and experimental transmission
Auteurs : C. P. Geret [Suisse] ; V. Cattori [Suisse] ; M. L. Meli [Suisse] ; B. Riond [Suisse] ; F. Martínez [Espagne] ; G. L Pez [Espagne] ; A. Vargas [Espagne] ; M. A. Sim N [Espagne] ; J. V. L Pez-Bao [Espagne] ; R. Hofmann-Lehmann [Suisse] ; H. Lutz [Suisse]Source :
- Archives of Virology [ 0304-8608 ] ; 2011-05-01.
Abstract
Abstract: The Iberian lynx is the most endangered felid species. During winter/spring 2006/7, a feline leukemia virus (FeLV) outbreak of unexpected virulence killed about 2/3 of the infected Iberian lynxes. All FeLV-positive animals were co-infected with feline hemoplasmas. To further characterize the Iberian lynx FeLV strain and evaluate its potential virulence, the FeLV envelope gene variable region A (VRA) mutant spectrum was analyzed using the Roche 454 sequencing technology, and an in vivo transmission study of lynx blood to specified-pathogen-free cats was performed. VRA mutations indicated weak apolipoprotein B mRNA editing enzyme and catalytic polypeptide-like cytidine deaminase (APOBEC) restriction of FeLV replication, and variants characteristic of aggressive FeLV strains, such as FeLV-C or FeLV-A/61C, were not detected. Cats exposed to FeLV/Candidatus Mycoplasma haemominutum-positive lynx blood did not show a particularly severe outcome of infection. The results underscore the special susceptibility of Iberian lynxes to infectious diseases.
Url:
DOI: 10.1007/s00705-011-0925-z
Affiliations:
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Lutz</name><affiliation wicri:level="4"><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2011-05-01">2011-05-01</date><biblScope unit="volume">156</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="839">839</biblScope><biblScope unit="page" to="854">854</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The Iberian lynx is the most endangered felid species. During winter/spring 2006/7, a feline leukemia virus (FeLV) outbreak of unexpected virulence killed about 2/3 of the infected Iberian lynxes. All FeLV-positive animals were co-infected with feline hemoplasmas. To further characterize the Iberian lynx FeLV strain and evaluate its potential virulence, the FeLV envelope gene variable region A (VRA) mutant spectrum was analyzed using the Roche 454 sequencing technology, and an in vivo transmission study of lynx blood to specified-pathogen-free cats was performed. VRA mutations indicated weak apolipoprotein B mRNA editing enzyme and catalytic polypeptide-like cytidine deaminase (APOBEC) restriction of FeLV replication, and variants characteristic of aggressive FeLV strains, such as FeLV-C or FeLV-A/61C, were not detected. Cats exposed to FeLV/Candidatus Mycoplasma haemominutum-positive lynx blood did not show a particularly severe outcome of infection. The results underscore the special susceptibility of Iberian lynxes to infectious diseases.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Suisse</li></country><region><li>Canton de Zurich</li></region><settlement><li>Zurich</li></settlement><orgName><li>Université de Zurich</li></orgName></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Geret, C P" sort="Geret, C P" uniqKey="Geret C" first="C. P." last="Geret">C. P. Geret</name></region><name sortKey="Cattori, V" sort="Cattori, V" uniqKey="Cattori V" first="V." last="Cattori">V. Cattori</name><name sortKey="Cattori, V" sort="Cattori, V" uniqKey="Cattori V" first="V." last="Cattori">V. Cattori</name><name sortKey="Hofmann Lehmann, R" sort="Hofmann Lehmann, R" uniqKey="Hofmann Lehmann R" first="R." last="Hofmann-Lehmann">R. Hofmann-Lehmann</name><name sortKey="Lutz, H" sort="Lutz, H" uniqKey="Lutz H" first="H." last="Lutz">H. Lutz</name><name sortKey="Meli, M L" sort="Meli, M L" uniqKey="Meli M" first="M. L." last="Meli">M. L. Meli</name><name sortKey="Riond, B" sort="Riond, B" uniqKey="Riond B" first="B." last="Riond">B. Riond</name></country><country name="Espagne"><noRegion><name sortKey="Martinez, F" sort="Martinez, F" uniqKey="Martinez F" first="F." last="Martínez">F. Martínez</name></noRegion><name sortKey="L Pez Bao, J V" sort="L Pez Bao, J V" uniqKey="L Pez Bao J" first="J. V." last="L Pez-Bao">J. V. L Pez-Bao</name><name sortKey="L Pez, G" sort="L Pez, G" uniqKey="L Pez G" first="G." last="L Pez">G. L Pez</name><name sortKey="Sim N, M A" sort="Sim N, M A" uniqKey="Sim N M" first="M. A." last="Sim N">M. A. Sim N</name><name sortKey="Vargas, A" sort="Vargas, A" uniqKey="Vargas A" first="A." last="Vargas">A. Vargas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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